GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs997295 | 1 | rs997295 | chr15:68016343 | MAP2K5 | chr15:67835021-68099451:+ | 0.14 | 3.48 | 0.000539 | Motion sickness |
| THCA | cis | rs7573615 | 1 | rs9973718 | chr2:53224326 | CHAC2 | chr2:53994929-54002287:+ | 0.22 | 3.45 | 0.000618 | Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs2839627 | 1 | rs9975986 | chr21:44458961 | PKNOX1 | chr21:44394643-44453688:+ | 0.33 | 4.56 | 6.46E-6 | Information processing speed |
| THCA | cis | rs9981595 | 1 | rs9981595 | chr21:40560678 | HMGN1 | chr21:40714247-40721270:- | -0.24 | -3.87 | 0.000125 | Venous thromboembolism (SNP x SNP interaction) |
| THCA | cis | rs2834188 | 1 | rs9982088 | chr21:34686841 | IFNAR1 | chr21:34696734-34732126:+ | 0.22 | 5.34 | 1.46E-7 | Narcolepsy |
| THCA | cis | rs2839627 | 1 | rs9984563 | chr21:44423653 | PKNOX1 | chr21:44394643-44453688:+ | 0.34 | 4.61 | 5.25E-6 | Information processing speed |
| THCA | cis | rs2832191 | 1 | rs9984793 | chr21:30486471 | C21orf7 | chr21:30449812-30548200:+ | 0.2 | 3.9 | 0.00011 | Dental caries |
| THCA | cis | rs10935120 | 1 | rs9985356 | chr3:134232920 | ANAPC13 | chr3:134196547-134204865:- | -0.38 | -12 | 3.66E-29 | Height |
| THCA | cis | rs10935120 | 1 | rs9985356 | chr3:134232920 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.45 | 2.76E-10 | Height |
| THCA | cis | rs1056667 | 1 | rs9986382 | chr6:26550619 | BTN2A3 | chr6:26422317-26431927:+ | 0.17 | 4.1 | 4.87E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs9986382 | chr6:26550619 | HCG11 | chr6:26521934-26527610:+ | -0.21 | -4.11 | 4.68E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs9986382 | chr6:26550619 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4 | 7.44E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs9986382 | chr6:26550619 | ZNF322A | chr6:26634612-26659963:- | -0.16 | -4.4 | 1.34E-5 | Educational attainment |
| THCA | cis | rs853679 | 1 | rs9986596 | chr6:28219661 | ZKSCAN3 | chr6:28317691-28334523:+ | -0.25 | -4.64 | 4.46E-6 | Depression |
| THCA | cis | rs853679 | 1 | rs9986596 | chr6:28219661 | ZNF187 | chr6:28234788-28245978:+ | -0.36 | -7.08 | 5.03E-12 | Depression |